Reaction Details Report a problem with these data
Target
Cytochrome b
Ligand
BDBM50487144
Substrate
n/a
Meas. Tech.
ChEMBL_908680 (CHEMBL3066175)
Ki
3.1±n/a nM
Citation
 Zhao, PL; Wang, L; Zhu, XL; Huang, X; Zhan, CG; Wu, JW; Yang, GF Subnanomolar inhibitor of cytochrome bc1 complex designed by optimizing interaction with conformationally flexible residues. J Am Chem Soc 132:185-94 (2010) [PubMed]  Article 
Target
Name:
Cytochrome b
Synonyms:
COB | CYB_PIG | CYTB | Complex III subunit 3 | Complex III subunit III | Cytochrome b | Cytochrome b-c1 complex subunit 3 | MT-CYB | MTCYB | Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Type:
PROTEIN
Mol. Mass.:
42786.51
Organism:
Sus scrofa
Description:
ChEMBL_106569
Residue:
379
Sequence:
MTNIRKSHPLMKIINNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWVIRYLHANGASMFFICLFIHVGRGLYYGSYMFLETWNIGVVLLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVEWIWGGFSVDKATLTRFFAFHFILPFIITALAAVHLLFLHETGSNNPTGISSDMDKIPFHPYYTIKDILGALFMMLILLILVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVASILILILMPMLHTSKQRGMMFRPLSQCLFWMLVADLITLTWIGGQPVEHPFIIIGQLASILYFLIILVLMPITSIIENNLLKW
  
Inhibitor
Name:
BDBM50487144
Synonyms:
CHEMBL2251794
Type:
Small organic molecule
Emp. Form.:
C23H24N2O5
Mol. Mass.:
408.4471
SMILES:
CO\C=C(\C(=O)OC)c1ccccc1COc1cc(nn1C)-c1cc(C)ccc1O
Structure:
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