Reaction Details Report a problem with these data
Target
Neutrophil collagenase
Ligand
BDBM50031778
Substrate
n/a
Meas. Tech.
ChEMBL_49517 (CHEMBL660241)
Ki
2±n/a nM
Citation
Gowravaram, MR; Tomczuk, BE; Johnson, JS; Delecki, D; Cook, ER; Ghose, AK; Mathiowetz, AM; Spurlino, JC; Rubin, B; Smith, DL Inhibition of matrix metalloproteinases by hydroxamates containing heteroatom-based modifications of the P1' group. J Med Chem 38:2570-81 (1995) [PubMed] Article
More Info.:
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
Inhibitor
Name:
BDBM50031778
Synonyms:
(R)-2-(4-(benzyloxy)butyl)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl)succinamide | (R)-2-(4-Benzyloxy-butyl)-N*4*-hydroxy-N*1*-((S)-1-methylcarbamoyl-2-phenyl-ethyl)-succinamide | CHEMBL87229
Type:
Small organic molecule
Emp. Form.:
C25H33N3O5
Mol. Mass.:
455.5466
SMILES:
CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCOCc1ccccc1)CC(=O)NO