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Target
Deoxyhypusine synthase
Ligand
BDBM50032489
Substrate
n/a
Meas. Tech.
ChEMBL_53735 (CHEMBL663660)
IC50
112000±n/a nM
Citation
 Lee, YB; Park, MH; Folk, JE Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity. J Med Chem 38:3053-61 (1995) [PubMed]  Article 
Target
Name:
Deoxyhypusine synthase
Synonyms:
DHYS_RAT | Dhps
Type:
PROTEIN
Mol. Mass.:
40696.63
Organism:
Rattus norvegicus
Description:
ChEMBL_53735
Residue:
369
Sequence:
MEGTPSGAAPSSALAAVLKHSSALPPESAQVQGYDFNRGVDYHALLEAYGTTGFQATNFGRAVQQVNAMIEKKLEPLAVDEDHHEDLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNDNYCKFEDWLMPILDQMVQEQNTEGVKWTPSKMISRLGKEINNPESVYYWAHKNHIPVLSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINMQAIFAKRTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAETFAQKADAFRAEKNED
  
Inhibitor
Name:
BDBM50032489
Synonyms:
CHEMBL75214 | N-(6-Guanidino-hexyl)-guanidine
Type:
Small organic molecule
Emp. Form.:
C8H20N6
Mol. Mass.:
200.2846
SMILES:
NC(=N)NCCCCCCNC(N)=N
Structure:
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