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Target
Interleukin-2
Ligand
BDBM50422041
Substrate
n/a
Meas. Tech.
ChEMBL_89079 (CHEMBL698590)
IC50
13±n/a nM
Citation
 Mikol, V; Papageorgiou, C; Borer, X The role of water molecules in the structure-based design of (5-hydroxynorvaline)-2-cyclosporin: synthesis, biological activity, and crystallographic analysis with cyclophilin A. J Med Chem 38:3361-7 (1995) [PubMed]  Article 
Target
Name:
Interleukin-2
Synonyms:
IL2_MOUSE | Il-2 | Il2 | T-cell growth factor | TCGF
Type:
PROTEIN
Mol. Mass.:
19394.78
Organism:
Mus musculus
Description:
ChEMBL_89079
Residue:
169
Sequence:
MYSMQLASCVTLTLVLLVNSAPTSSSTSSSTAEAQQQQQQQQQQQQHLEQLLMDLQELLSRMENYRNLKLPRMLTFKFYLPKQATELKDLQCLEDELGPLRHVLDLTQSKSFQLEDAENFISNIRVTVVKLKGSDNTFECQFDDESATVVDFLRRWIAFCQSIISTSPQ
  
Inhibitor
Name:
BDBM50422041
Synonyms:
GECLOSPORIN
Type:
Small organic molecule
Emp. Form.:
C63H113N11O12
Mol. Mass.:
1216.6378
SMILES:
CCC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
Structure:
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