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Target
Reverse transcriptase/RNaseH
Ligand
BDBM1368
Substrate
n/a
Meas. Tech.
ChEMBL_196795 (CHEMBL802186)
IC50
30±n/a nM
Citation
 Schäfer, W; Friebe, WG; Leinert, H; Mertens, A; Poll, T; von der Saal, W; Zilch, H; Nuber, B; Ziegler, ML Non-nucleoside inhibitors of HIV-1 reverse transcriptase: molecular modeling and X-ray structure investigations. J Med Chem 36:726-32 (1993) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM1368
Synonyms:
9b-(3-methylphenyl)-2H,3H,5H,9bH-isoindolo[1,2-b][1,3]thiazol-5-one | CHEMBL85446 | Thiazoloisoindol-5-one deriv. 13
Type:
Small organic molecule
Emp. Form.:
C17H15NOS
Mol. Mass.:
281.372
SMILES:
Cc1cccc(c1)C12SCCN1C(=O)c1ccccc21
Structure:
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