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Target
Endothelin-1 receptor
Ligand
BDBM50029770
Substrate
n/a
Meas. Tech.
ChEMBL_63217 (CHEMBL674069)
IC50
4000±n/a nM
Citation
Stein, PD; Floyd, DM; Bisaha, S; Dickey, J; Girotra, RN; Gougoutas, JZ; Kozlowski, M; Lee, VG; Liu, EC; Malley, MF Discovery and structure-activity relationships of sulfonamide ETA-selective antagonists. J Med Chem 38:1344-54 (1995) [PubMed] Article
More Info.:
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48256.91
Organism:
RAT
Description:
ENDOTHELIN A EDNRA RAT::P26684
Residue:
426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
Inhibitor
Name:
BDBM50029770
Synonyms:
4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonamide | 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide | ACETYLSULFAMETHOXAZOLE | BACTRIM | CHEMBL443 | COTRIM | GANTANOL | GANTANOL-DS | RO 4-2130 | SEPTRA | SULFAMETHOPRIM | SULFAMETHOPRIM-DS | SULFAMETHOXAZOLE SODIUM | SULFATRIM | SULFATRIM-DS | SULFATRIM-SS | SULMEPRIM | SULPHAMETHOXAZOLE | TRIMETH/SULFA | UROBAK
Type:
Small organic molecule
Emp. Form.:
C10H11N3O3S
Mol. Mass.:
253.278
SMILES:
Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1