Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50001862
Substrate
n/a
Meas. Tech.
ChEMBL_1192 (CHEMBL615958)
Ki
170±n/a nM
Citation
 Kuipers, W; van Wijngaarden, I; Kruse, CG; ter Horst-van Amstel, M; Tulp, MT; IJzerman, AP N4-unsubstituted N1-arylpiperazines as high-affinity 5-HT1A receptor ligands. J Med Chem 38:1942-54 (1995) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50001862
Synonyms:
(N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl)-piperazine | 1-(2-Methoxy-phenyl)-piperazine | 2-METHOXYPHENYLPIPERAZINE | 4-(2-Methoxy-phenyl)-piperazin-1-ium | CHEMBL9666 | EN300-33366
Type:
Small organic molecule
Emp. Form.:
C11H16N2O
Mol. Mass.:
192.2575
SMILES:
COc1ccccc1N1CCNCC1
Structure:
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