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Target
Presenilin-1
Ligand
BDBM50492083
Substrate
n/a
Meas. Tech.
ChEMBL_968577 (CHEMBL2401297)
IC50
0.570000±n/a nM
Citation
 Ye, XM; Konradi, AW; Sun, M; Yuan, S; Aubele, DL; Dappen, M; Dressen, D; Garofalo, AW; Jagodzinski, JJ; Latimer, L; Probst, GD; Sham, HL; Wone, D; Xu, YZ; Ness, D; Brigham, E; Kwong, GT; Willtis, C; Tonn, G; Goldbach, E; Quinn, KP; Zhang, HH; Sauer, JM; Bova, M; Basi, GS Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious ?-secretase inhibitors. Bioorg Med Chem Lett 23:996-1000 (2013) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50492083
Synonyms:
CHEMBL2396960
Type:
Small organic molecule
Emp. Form.:
C19H13ClF3N3O2S
Mol. Mass.:
439.839
SMILES:
[H][C@]12Cc3n[nH]cc3[C@]([H])(N1S(=O)(=O)c1cccc(c1)C(F)(F)F)c1cc(Cl)ccc21 |r,THB:11:10:30.24:2.7.3|
Structure:
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