Target
Amyloid-beta precursor protein
Ligand
BDBM50122787
Substrate
n/a
Meas. Tech.
ChEMBL_968258 (CHEMBL2399572)
Ki
11±n/a nM
Citation
 Fu, HYu, LCui, MZhang, JZhang, XLi, ZWang, XJia, JYang, YYu, PJia, HLiu, B Synthesis and biological evaluation of 18F-labled 2-phenylindole derivatives as PET imaging probes for ?-amyloid plaques. Bioorg Med Chem 21:3708-14 (2013) [PubMed]  Article 
Target
Name:
Amyloid-beta precursor protein
Synonyms:
A4 | A4_HUMAN | ABPP | AD1 | AICD-50 | AICD-57 | AICD-59 | AID(50) | AID(57) | AID(59) | APP | APPI | Alzheimer disease amyloid protein | Amyloid beta A4 protein | Amyloid beta Protein | Amyloid beta protein (sAPPbeta) | Amyloid beta protein Abeta(1-42) | Amyloid intracellular domain 50 | Amyloid intracellular domain 57 | Amyloid intracellular domain 59 | Amyloid protein (Abeta42b) | Amyloid β-protein (Aβ42) | Beta amyloid A4 protein | Beta-APP40 | Beta-APP42 | Beta-amyloid protein 40 | Beta-amyloid protein 42 | C31 | C83 | C99 | CVAP | Cerebral vascular amyloid peptide | Gamma Secretase | Gamma-CTF(50) | Gamma-CTF(57) | Gamma-CTF(59) | Gamma-secretase | Gamma-secretase C-terminal fragment 50 | Gamma-secretase C-terminal fragment 57 | Gamma-secretase C-terminal fragment 59 | P3(40) | P3(42) | PN-II | PreA4 | Protease nexin-II | S-APP-alpha | S-APP-beta | Soluble APP-alpha | Soluble APP-beta | beta-Amyloid Precursor Protein (APP)
Type:
Single-pass type I membrane protein
Mol. Mass.:
86890.41
Organism:
Homo sapiens (Human)
Description:
P05067
Residue:
770
Sequence:
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
  
Inhibitor
Name:
BDBM50122787
Synonyms:
2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine | 4-(6-iodoH-imidazo[1,2-a]pyridin-2-yl)-N,N-dimethylbenzenamine | 4-(6-iodoimidazo[1,2-a]pyridin-2-yl)-N,N-dimethylaniline | 6-iodo-2-(4'-N,N'-dimethylamino)phenylimidazo[1,2-a]pyridine) | 6-iodo-2-(4'-dimethylamino)phenyl-imidazo[1,2-a]pyridine | 6-iodo-2-(4'-dimethylamino-)phenyl-imidazo[1,2]pyridine | CHEMBL78012 | [4-(6-Iodo-imidazo[1,2-a]pyridin-2-yl)-phenyl]-dimethyl-amine
Type:
Small organic molecule
Emp. Form.:
C15H14IN3
Mol. Mass.:
363.1962
SMILES:
CN(C)c1ccc(cc1)-c1cn2cc(I)ccc2n1
Structure:
Search PDB for entries with ligand similarity: