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Target
Leukotriene B4 receptor 1
Ligand
BDBM50037218
Substrate
n/a
Meas. Tech.
ChEMBL_99485 (CHEMBL704373)
IC50
9.7±n/a nM
Citation
 Koch, K; Melvin, LS; Reiter, LA; Biggers, MS; Showell, HJ; Griffiths, RJ; Pettipher, ER; Cheng, JB; Milici, AJ; Breslow, R (+)-1-(3S,4R)-[3-(4-phenylbenzyl)-4-hydroxychroman-7-yl]cyclopentane carboxylic acid, a highly potent, selective leukotriene B4 antagonist with oral activity in the murine collagen-induced arthritis model. J Med Chem 37:3197-9 (1994) [PubMed]  Article 
Target
Name:
Leukotriene B4 receptor 1
Synonyms:
BLT | BLT1 | BLTR | CMKRL1 | Chemoattractant receptor-like 1 | G-protein coupled receptor 16 | GPR16 | LT4R1_HUMAN | LTB4-R 1 | LTB4R | Leukotriene B4 R1 | Leukotriene B4 receptor | Leukotriene B4 receptor 1 | P2RY7 | P2Y purinoceptor 7 | P2Y7
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37582.68
Organism:
Homo sapiens (Human)
Description:
Q15722
Residue:
352
Sequence:
MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
  
Inhibitor
Name:
BDBM50037218
Synonyms:
1-((3S,4R)-3-Biphenyl-4-ylmethyl-4-hydroxy-chroman-7-yl)-cyclopentanecarboxylic acid | CHEMBL51770 | CP-105696
Type:
Small organic molecule
Emp. Form.:
C28H28O4
Mol. Mass.:
428.5195
SMILES:
O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)C1(CCCC1)C(O)=O
Structure:
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