Reaction Details Report a problem with these data
Target
Neuropeptide FF receptor 2
Ligand
BDBM50037563
Substrate
n/a
Meas. Tech.
ChEMBL_143663 (CHEMBL755904)
Ki
0.5±n/a nM
Citation
 Gicquel, S; Mazarguil, H; Desprat, C; Allard, M; Devillers, JP; Simonnet, G; Zajac, JM Structure-activity study of neuropeptide FF: contribution of N-terminal regions to affinity and activity. J Med Chem 37:3477-81 (1994) [PubMed]  Article 
Target
Name:
Neuropeptide FF receptor 2
Synonyms:
G-protein coupled receptor 74 | Gpr74 | NPFF2_RAT | Neuropeptide G-protein coupled receptor | Npff2 | Npffr2 | Npgpr
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47725.66
Organism:
RAT
Description:
NPFF2 0 RAT::Q9EQD2
Residue:
417
Sequence:
MGKRWDSNSSGSWDHIWSGNDTQHPWYSDINITYMNYYLHQPHVTAVFISSYFLIFFLCMVGNTVVCFVVIRNRYMHTVTNFFIFNLAISDLLVGIFCMPITLLDNIIAGWPFGSSMCKISGLVQGISVAASVFTLVAIAVDRFRCVVYPFKPKLTVKTAFVMIVIIWGLAITIMTPSAIMLHVQEEKYYRVRLSSHNKTSTVYWCREDWPNQEMRRIYTTVLFATIYLAPLSLIVIMYARIGASLFKTSAHSTGKQRLEQWHVSKKKQKVIKMLLTVALLFILSWLPLWTLMMLSDYADLSPNKLRVINIYVYPFAHWLAFCNSSVNPIIYGFFNENFRSGFQDAFQFCQKKVKPQEAYGLRAKRNLDINTSGLLVHEPASQNPSGENLGCRKSADNPTQESLMEETGEATNSTET
  
Inhibitor
Name:
BDBM50037563
Synonyms:
2-{[1-(2-{2-[2-(2-Amino-3-(p-hydroxyphenyl)-propionylamino)-4-methyl-pentanoylamino]-3-phenyl-propionylmethylamino}-4-carbamoyl-butyryl)-pyrrolidine-2-carbonyl]-amino}-pentanedioic acid 5-amide 1-{[1-(1-carbamoyl-2-phenyl-ethylcarbamoyl)-4-guanidino-butyl]-amide} | CHEMBL410577
Type:
Small organic molecule
Emp. Form.:
C54H76N14O11
Mol. Mass.:
1097.2684
SMILES:
CC(C)C[C@@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Structure:
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