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Target
Nociceptin receptor
Ligand
BDBM50492402
Substrate
n/a
Meas. Tech.
ChEMBL_971898 (CHEMBL2405348)
EC50
1413±n/a nM
Citation
 Zamfirova, R; Pavlov, N; Todorov, P; Mateeva, P; Martinez, J; Calmès, M; Naydenova, E Synthesis and changes in affinity for NOP and opioid receptors of novel hexapeptides containing ?(2)-tryptophan analogues. Bioorg Med Chem Lett 23:4052-5 (2013) [PubMed]  Article 
Target
Name:
Nociceptin receptor
Synonyms:
Nociceptin/Orphanin FQ, NOP receptor | Nociceptin/mu opioid receptor | OPRX_RAT | Oor | Oprl | Oprl1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40531.08
Organism:
RAT
Description:
Nociceptin/Orphanin FQ, NOP receptor 0 RAT::P35370
Residue:
367
Sequence:
MESLFPAPYWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASSLHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
  
Inhibitor
Name:
BDBM50492402
Synonyms:
CHEMBL2403216
Type:
Small organic molecule
Emp. Form.:
C50H71N15O10
Mol. Mass.:
1042.1932
SMILES:
COc1ccc2[nH]cc([C@H](CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CCCCN)C(N)=O)c2c1 |r|
Structure:
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