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TargetLeukocyte elastase
LigandBDBM50291929
Substrate/Competitorn/a
Meas. Tech.ChEMBL_64660
KON 3.9 M-1s-1
Citation Alpegiani, MBissolino, PCorigli, RDel Nero, SPerrone, ERizzo, VSacchi, NCassinelli, GFranceschi, GBaici, A Cephem sulfones as inactivators of human leukocyte elastase. 5. 7 alpha-Methoxy- and 7 alpha-chloro-1,1-dioxocephem 4-ketones. J Med Chem37:4003-19 (1994) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Leukocyte elastase
Name:Leukocyte elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50291929
NameBDBM50291929
Synonyms:(4S,7S)-2-Benzoyl-7-methoxy-4-(5-methyl-2,5-dihydro-[1,3,4]thiadiazol-2-ylsulfanyl)-3-(5-methyl-2,5-dihydro-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-5,5-dioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-en-8-one | CHEMBL177637
TypeSmall organic molecule
Emp. Form.C21H23N5O5S5
Mol. Mass.585.763
SMILESCO[C@@H]1C2N(C1=O)C(C(=O)c1ccccc1)=C(CSC1=NNC(C)S1)[C@@H](SC1=NNC(C)S1)S2(=O)=O |t:17,21,30|
Structure
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