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TargetLeukocyte elastase
LigandBDBM50291937
Substrate/Competitorn/a
Meas. Tech.ChEMBL_64660
KON 4.9 M-1s-1
Citation Alpegiani, MBissolino, PCorigli, RDel Nero, SPerrone, ERizzo, VSacchi, NCassinelli, GFranceschi, GBaici, A Cephem sulfones as inactivators of human leukocyte elastase. 5. 7 alpha-Methoxy- and 7 alpha-chloro-1,1-dioxocephem 4-ketones. J Med Chem37:4003-19 (1994) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Leukocyte elastase
Name:Leukocyte elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50291937
NameBDBM50291937
Synonyms:Acetic acid (S)-7-chloro-5,5,8-trioxo-2-phenylacetyl-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl ester | CHEMBL128290
TypeSmall organic molecule
Emp. Form.C17H16ClNO6S
Mol. Mass.397.83
SMILESCC(=O)OCC1=C(N2C([C@@H](Cl)C2=O)S(=O)(=O)C1)C(=O)Cc1ccccc1 |t:5|
Structure
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n/a