Target
ATP-dependent Clp protease proteolytic subunit, mitochondrial
Ligand
BDBM50502329
Substrate
n/a
Meas. Tech.
ChEMBL_1806443 (CHEMBL4305802)
IC50
117600±n/a nM
Citation
 Tan, JGrouleff, JJJitkova, YDiaz, DBGriffith, ECShao, WBogdanchikova, AFPoda, GSchimmer, ADLee, REYudin, AK De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX. J Med Chem 62:6377-6390 (2019) [PubMed]  Article 
Target
Name:
ATP-dependent Clp protease proteolytic subunit, mitochondrial
Synonyms:
3.4.21.92 | ATP-dependent Clp protease proteolytic subunit, mitochondrial | CLPP | CLPP_HUMAN | Endopeptidase Clp
Type:
PROTEIN
Mol. Mass.:
30185.26
Organism:
Homo sapiens
Description:
ChEMBL_119055
Residue:
277
Sequence:
MWPGILVGGARVASCRYPALGPRLAAHFPAQRPPQRTLQNGLALQRCLHATATRALPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEPTLVQKEPVEAAPAAEPVPAST
  
Inhibitor
Name:
BDBM50502329
Synonyms:
CHEMBL4451932
Type:
Small organic molecule
Emp. Form.:
C22H28BClN2O5
Mol. Mass.:
446.732
SMILES:
COc1ccc(C(=O)NC(CC(C)C)C(=O)NC(Cc2ccccc2)B(O)O)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: