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Target
Purine nucleoside phosphorylase
Ligand
BDBM50039551
Substrate
n/a
Meas. Tech.
ChEMBL_162035 (CHEMBL766675)
Ki
45±n/a nM
Citation
 Niwas, S; Chand, P; Pathak, VP; Montgomery, JA Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines. J Med Chem 37:2477-80 (1994) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Np | PNPH_RAT | Pnp | Purine nucleoside phosphorylase | Purine-nucleoside phosphorylase | nucleoside phosphorylase
Type:
PROTEIN
Mol. Mass.:
32303.61
Organism:
Rattus norvegicus
Description:
ChEMBL_162034
Residue:
289
Sequence:
MENEFTYEDYQRTAEWLRSHTKHRPQVAVICGSGLGGLTAKLTQPQAFDYNEIPNFPQSTVQGHAGRLVFGFLNGRSCVMMQGRFHMYEGYSLSKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFCGQNPLRGPNDERFGVRFPAMSDAYDRDMRQKAFNAWKQMGEQRELQEGTYIMSAGPTFETVAESCLLRMLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVVMDYNNLEKASHQEVLEAGKAAAQKLEQFVSILMESIPPRERAN
  
Inhibitor
Name:
BDBM50039551
Synonyms:
CHEMBL13448 | [5-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-3,3-dimethyl-pentyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C12H20N5O4P
Mol. Mass.:
329.2921
SMILES:
CC(C)(CCn1cnc2c1nc(N)[nH]c2=O)CCP(O)(O)=O
Structure:
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