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Target
Vesicular acetylcholine transporter
Ligand
BDBM50039602
Substrate
n/a
Meas. Tech.
ChEMBL_213554 (CHEMBL816914)
Ki
0.41±n/a nM
Citation
 Efange, SM; Khare, AB; Foulon, C; Akella, SK; Parsons, SM Spirovesamicols: conformationally restricted analogs of 2-(4-phenylpiperidino)cyclohexanol (vesamicol, AH5183) as potential modulators of presynaptic cholinergic function. J Med Chem 37:2574-82 (1994) [PubMed]  Article 
Target
Name:
Vesicular acetylcholine transporter
Synonyms:
TorVAChT | VACHT_TETCF | VAChT
Type:
PROTEIN
Mol. Mass.:
56111.93
Organism:
Torpedo californica
Description:
ChEMBL_1503355
Residue:
515
Sequence:
MGVTMAVGLAKAAMGKISSAIGERSKRISGAMNEPRRKRKILLVIVCIAMLLDNMLYMVIVPIIPNYLETIRTYKLVYITTPSNGTNGSLLNSTQRAVLERNPNANEDIQIGVLFASKAILQLLSNPFTGTFIDRVGYDIPLLIGLTIMFFSTITFAFGESYAVLFAARSLQGLGSAFADTSGIAMIADKYTEESERTQALGIALAFISFGSLVAPPFGGVLYQFAGKWVPFLVLSFVCLLDGILLLMVVTPFASRTRENMLQGTPIYKLMIDPYIAVVAGALTTCNIPLAFLEPTISNWMKKTMNASEWQMGITWLPAFFPHILGVYITVKLAAKYPNYQWFYGAVGLVIIGASSCTIPACRNFEELIIPLCALCFGIALVDTALLPTLAFLVDIRYVSVYGSVYAIADISYSVAYALGPIMAGQIVHDLGFVQLNLGMGLVNILYAPALLFLRNVCQMKPSLSERNILLEEGPKGLYDTIIMEERKAAKEPHGSSSGNHSVHAVLSDQEGYSE
  
Inhibitor
Name:
BDBM50039602
Synonyms:
(2R,3R)-3-(2-bromo-1'H-spiro[indene-1,4'-piperidin]-1'-yl)-1,2,3,4-tetrahydronaphthalen-2-ol | CHEMBL406130
Type:
Small organic molecule
Emp. Form.:
C23H24BrNO
Mol. Mass.:
410.347
SMILES:
O[C@@H]1Cc2ccccc2C[C@H]1N1CCC2(CC1)C(Br)=Cc1ccccc21 |c:21|
Structure:
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