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Target
Mu-type opioid receptor
Ligand
BDBM50494228
Substrate
n/a
Meas. Tech.
ChEMBL_1277199 (CHEMBL3088919)
Ki
0.430000±n/a nM
Citation
 Carroll, FI; Gichinga, MG; Williams, JD; Vardy, E; Roth, BL; Mascarella, SW; Thomas, JB; Navarro, HA 4?-Methyl-5-(3-hydroxyphenyl)morphan opioid agonist and partial agonist derived from a 4?-methyl-5-(3-hydroxyphenyl)morphan pure antagonist. J Med Chem 56:8826-33 (2013) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50494228
Synonyms:
CHEMBL3217271
Type:
Small organic molecule
Emp. Form.:
C29H42Cl2N2O
Mol. Mass.:
505.563
SMILES:
Cl.Cl.[H][C@]12C[C@@H](C[C@](C1)([C@H](C)CN2CCCc1ccccc1)c1cccc(O)c1)N(C)CC1CC1 |r,TLB:10:9:8:6.4.5,THB:13:12:8:6.4.5|
Structure:
Search PDB for entries with ligand similarity: