Reaction Details Report a problem with these data
Target
Phospholipase A2, major isoenzyme
Ligand
BDBM50031087
Substrate
n/a
Meas. Tech.
ChEMBL_156364 (CHEMBL761694)
IC50
1100±n/a nM
Citation
 Wilkerson, WW; Galbraith, W; Gans-Brangs, K; Grubb, M; Hewes, WE; Jaffee, B; Kenney, JP; Kerr, J; Wong, N Antiinflammatory 4,5-diarylpyrroles: synthesis and QSAR. J Med Chem 37:988-98 (1994) [PubMed]  Article 
Target
Name:
Phospholipase A2, major isoenzyme
Synonyms:
Group IB phospholipase A2 | PA21B_PIG | PLA2G1B | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2
Type:
Hydrolase; monomer or homodimer
Mol. Mass.:
16279.83
Organism:
Sus scrofa (pig)
Description:
Purchased from Sigma.
Residue:
146
Sequence:
MKFLVLAVLLTVGAAQEGISSRALWQFRSMIKCAIPGSHPLMDFNNYGCYCGLGGSGTPVDELDRCCETHDNCYRDAKNLDSCKFLVDNPYTESYSYSCSNTEITCNSKNNACEAFICNCDRNAAICFSKAPYNKEHKNLDTKKYC
  
Inhibitor
Name:
BDBM50031087
Synonyms:
3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-5-thiocyanato-1H-pyrrole | CHEMBL126345
Type:
Small organic molecule
Emp. Form.:
C18H13FN2O2S2
Mol. Mass.:
372.436
SMILES:
CS(=O)(=O)c1ccc(cc1)-c1[nH]c(SC#N)cc1-c1ccc(F)cc1
Structure:
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