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Target
Protein kinase C delta type
Ligand
BDBM50495192
Substrate
n/a
Meas. Tech.
ChEMBL_1284659 (CHEMBL3107240)
EC50
2.5±n/a nM
Citation
 Grue-Sørensen, G; Liang, X; Månsson, K; Vedsø, P; Dahl Sørensen, M; Soor, A; Stahlhut, M; Bertelsen, M; Engell, KM; Högberg, T Synthesis, biological evaluation and SAR of 3-benzoates of ingenol for treatment of actinic keratosis and non-melanoma skin cancer. Bioorg Med Chem Lett 24:54-60 (2014) [PubMed]  Article 
Target
Name:
Protein kinase C delta type
Synonyms:
KPCD_HUMAN | PKC delta | PKCD | PRKCD | Protein Kinase C- delta | Protein kinase C, PKC; classical/novel | nPKC-delta
Type:
Enzyme
Mol. Mass.:
77516.79
Organism:
Homo sapiens (Human)
Description:
The recombinant human PKC enzymes were produced using a baculovirus expression system in SF9 cells
Residue:
676
Sequence:
MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED
  
Inhibitor
Name:
BDBM50495192
Synonyms:
CHEMBL3105098
Type:
Small organic molecule
Emp. Form.:
C28H35NO6
Mol. Mass.:
481.5806
SMILES:
[H][C@@]12C[C@@H](C)[C@]34C=C(C)[C@H](OC(=O)c5ccccc5NC)[C@@]3(O)[C@H](O)C(CO)=C[C@]([H])(C4=O)[C@]1([H])C2(C)C |r,c:29,t:6|
Structure:
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