Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50001493
Substrate
n/a
Meas. Tech.
ChEBML_29009
Ki
32000±n/a nM
Citation
Müller, CE; Shi, D; Manning, M; Daly, JW Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors. J Med Chem 36:3341-9 (1993) [PubMed] Article
More Info.:
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1
Type:
Protein
Mol. Mass.:
36704.13
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
326
Sequence:
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
Inhibitor
Name:
BDBM50001493
Synonyms:
3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3,7-dihydro-purine-2,6-dione(enprofylline) | 3-Propylxanthine (enprofylline) | CHEMBL279898 | ENPROFYLLINE
Type:
Small organic molecule
Emp. Form.:
C8H10N4O2
Mol. Mass.:
194.1906
SMILES:
CCCn1c2nc[nH]c2c(=O)[nH]c1=O