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Target
Polyunsaturated fatty acid 5-lipoxygenase
Ligand
BDBM50009004
Substrate
n/a
Meas. Tech.
ChEBML_3921
IC50
1000±n/a nM
Citation
 Sogawa, S; Nihro, Y; Ueda, H; Izumi, A; Miki, T; Matsumoto, H; Satoh, T 3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors. J Med Chem 36:3904-9 (1994) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid 5-lipoxygenase
Synonyms:
Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT
Type:
PROTEIN
Mol. Mass.:
78082.31
Organism:
Rattus norvegicus
Description:
ChEMBL_1432947
Residue:
673
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDEELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGCNPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPCTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFHIHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGLFDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEAIQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYYYLSPDRIPNSVAI
  
Inhibitor
Name:
BDBM50009004
Synonyms:
(phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-pyrazolidin-3-one | 1-Phenyl-pyrazolidin-3-one (Phenidone) | 1-Phenyl-pyrazolidin-3-one(phenidone) | 1-phenylpyrazolidin-3-one | CHEMBL7660 | PHENIDONE
Type:
Small organic molecule
Emp. Form.:
C9H10N2O
Mol. Mass.:
162.1885
SMILES:
O=C1CCN(N1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: