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TargetSteroid 5-alpha-reductase
LigandBDBM50043612
Substrate/Competitorn/a
Meas. Tech.ChEMBL_88442
IC50 0.36±n/a nM
Citation Frye, SVHaffner, CDMaloney, PRMook, RADorsey, GFHiner, RNBatchelor, KWBramson, HNStuart, JDSchweiker, SL 6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5 alpha-reductase. J Med Chem36:4313-5 (1994) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Steroid 5-alpha-reductase
Name:Steroid 5-alpha-reductase
Synonyms:3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | SR type 2 | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:Enzyme
Mol. Mass.:28406.59
Organism:Homo sapiens (Human)
Description:P31213
Residue:254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS
FAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCT
GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI
PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE
DYPKSRKALIPFIF
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BDBM50043612
NameBDBM50043612
Synonyms:9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid diisopropylamide | CHEMBL137691
TypeSmall organic molecule
Emp. Form.C25H40N2O2
Mol. Mass.400.5973
SMILESCC(C)N(C(C)C)C(=O)[C@H]1CCC2C3CN=C4CC(=O)CC[C@]4(C)C3CC[C@]12C |t:15|
Structure
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