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Target
Polyunsaturated fatty acid 5-lipoxygenase
Ligand
BDBM50043670
Substrate
n/a
Meas. Tech.
ChEMBL_3866 (CHEMBL619382)
IC50
0.700000±n/a nM
Citation
 Lambert-van der Brempt, C; Bruneau, P; Lamorlette, MA; Foster, SJ Conformational analysis of 5-lipoxygenase inhibitors: role of the substituents in chiral recognition and on the active conformations of the (methoxyalkyl)thiazole and methoxytetrahydropyran series. J Med Chem 37:113-24 (1994) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid 5-lipoxygenase
Synonyms:
5-LO | 5-lipoxygenase | Alox5 | Arachidonate 5-lipoxygenase | LOX5_MOUSE
Type:
PROTEIN
Mol. Mass.:
77961.27
Organism:
Mus musculus
Description:
ChEMBL_675639
Residue:
674
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGAVDSYDVTVDEELGEIYLVKIEKRKYWLHDDWYLKYITLKTPHGDYIEFPCYRWITGEGEIVLRDGRAKLARDDQIHILKQHRRKELEARQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGCNPVLIKRCTALPPKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPCTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGESNPIFLPTDSKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLICEYGLFDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDSTEDIPFYFYRDDGLLVWEAIQSFTMEVVSIYYENDQVVEEDQELQDFVKDVYVYGMRGKKASGFPKSIKSREKLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYYYLSPDRIPNSVAI
  
Inhibitor
Name:
BDBM50043670
Synonyms:
2-{(S)-1-[3-Fluoro-5-(naphthalen-2-ylmethoxy)-phenyl]-1-methoxy-propyl}-thiazole | CHEMBL22106
Type:
Small organic molecule
Emp. Form.:
C24H22FNO2S
Mol. Mass.:
407.5
SMILES:
CC[C@@](OC)(c1nccs1)c1cc(F)cc(OCc2ccc3ccccc3c2)c1
Structure:
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