Reaction Details Report a problem with these data
Target
Histone-lysine N-methyltransferase SUV39H1
Ligand
BDBM50443019
Substrate
n/a
Meas. Tech.
ChEMBL_1299029 (CHEMBL3134894)
Ki
>50000±n/a nM
Citation
 Deng, L; Zhang, L; Yao, Y; Wang, C; Redell, MS; Dong, S; Song, Y Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L. Medchemcomm 4:822-826 (2013) [PubMed]  Article 
Target
Name:
Histone-lysine N-methyltransferase SUV39H1
Synonyms:
H3-K9-HMTase 1 | Histone H3-K9 methyltransferase 1 | KMT1A | Lysine N-methyltransferase 1A | Position-effect variegation 3-9 homolog | SUV39H | SUV39H1 | SUV91_HUMAN | Su(var)3-9 homolog 1 | Suppressor of variegation 3-9 homolog 1
Type:
PROTEIN
Mol. Mass.:
47917.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1473655
Residue:
412
Sequence:
MAENLKGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYYLVKWRGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRRHHRSKTPRHLDPSLANYLVQKAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVGCECQDCLWAPTGGCCPGASLHKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTESCRKYLF
  
Inhibitor
Name:
BDBM50443019
Synonyms:
CHEMBL3087502
Type:
Small organic molecule
Emp. Form.:
C28H40N8O3
Mol. Mass.:
536.669
SMILES:
CC(C)N(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)CC1=C[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r,t:23|
Structure:
Search PDB for entries with ligand similarity: