Reaction Details Report a problem with these data
Target
Sensory histidine kinase DcuS
Ligand
BDBM50497020
Substrate
n/a
Meas. Tech.
ChEMBL_1335394 (CHEMBL3239045)
Kd
4000±n/a nM
Citation
 Murray, EJ; Crowley, RC; Truman, A; Clarke, SR; Cottam, JA; Jadhav, GP; Steele, VR; O'Shea, P; Lindholm, C; Cockayne, A; Chhabra, SR; Chan, WC; Williams, P Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors. J Med Chem 57:2813-9 (2014) [PubMed]  Article 
Target
Name:
Sensory histidine kinase DcuS
Synonyms:
Receptor-histidine kinase AgrC
Type:
PROTEIN
Mol. Mass.:
49890.25
Organism:
Staphylococcus aureus
Description:
ChEMBL_305973
Residue:
430
Sequence:
MELLNSYNFVLFVLTQMILMFTIPAIISGIKYSKLDYFFIIVISTLSLFLFKMFDSASLIILTSFIIIMYFVKIKWYSILLIMTSQIILYCANYMYIVIYAYITKISDSIFVIFPSFFVVYVTISILFSYIINRVLKKISTPYLILNKGFLIVISTILLLTFSLFFFYSQINSDEAKVIRQYSFIFIGITIFLSILTFVISQFLLKEMKYKRNQEEIETYYEYTLKIEAINNEMRKFRHDYVNILTTLSEYIREDDMPGLRDYFNKNIVPMKDNLQMNAIKLNGIENLKVREIKGLITAKILRAQEMNIPISIEIPDEVSSINLNMIDLSRSIGIILDNAIEASTEIDDPIIRVAFIESENSVTFIVMNKCADDIPRIHELFQESFSTKGEGRGLGLSTLKEIADNADNVLLDTIIENGFFIQKVEIINN
  
Inhibitor
Name:
BDBM50497020
Synonyms:
CHEMBL3235590
Type:
Small organic molecule
Emp. Form.:
C18H30O4
Mol. Mass.:
310.4284
SMILES:
CCCCCCCCCCCCCC(=O)C1=C(O)COC1=O |c:15|
Structure:
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