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Target
Gastricsin
Ligand
BDBM50045288
Substrate
n/a
Meas. Tech.
ChEBML_71514
Ki
>4000±n/a nM
Citation
 Rao, CM; Scarborough, PE; Kay, J; Batley, B; Rapundalo, S; Klutchko, S; Taylor, MD; Lunney, EA; Humblet, CC; Dunn, BM Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J Med Chem 36:2614-20 (1993) [PubMed]  Article 
Target
Name:
Gastricsin
Synonyms:
Gastricsin | PEPC_HUMAN | PGC | Pepsinogen C
Type:
PROTEIN
Mol. Mass.:
42409.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1452207
Residue:
388
Sequence:
MKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAA
  
Inhibitor
Name:
BDBM50045288
Synonyms:
CHEMBL329220 | N-(1-Cyclohexylmethyl-2,4-dihydroxy-hexyl)-3-[2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-succinamic acid methyl ester
Type:
Small organic molecule
Emp. Form.:
C31H50N4O9S
Mol. Mass.:
654.815
SMILES:
CC[C@@H](O)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(=O)OC)NC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)N1CCOCC1
Structure:
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