Reaction Details Report a problem with these data
Target
Friend leukemia integration 1 transcription factor
Ligand
BDBM50497662
Substrate
n/a
Meas. Tech.
ChEMBL_1440214 (CHEMBL3383759)
IC50
180±n/a nM
Citation
 Tosso, PN; Kong, Y; Scher, L; Cummins, R; Schneider, J; Rahim, S; Holman, KT; Toretsky, J; Wang, K; Üren, A; Brown, ML Synthesis and structure-activity relationship studies of small molecule disruptors of EWS-FLI1 interactions in Ewing's sarcoma. J Med Chem 57:10290-303 (2014) [PubMed]  Article 
Target
Name:
Friend leukemia integration 1 transcription factor
Synonyms:
FLI1 | FLI1_HUMAN | Friend leukemia integration 1 transcription factor | Proto-oncogene Fli-1 | Transcription factor ERGB
Type:
PROTEIN
Mol. Mass.:
50985.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117112
Residue:
452
Sequence:
MDGTIKEALSVVSDDQSLFDSAYGAAAHLPKADMTASGSPDYGQPHKINPLPPQQEWINQPVRVNVKREYDHMNGSRESPVDCSVSKCSKLVGGGESNPMNYNSYMDEKNGPPPPNMTTNERRVIVPADPTLWTQEHVRQWLEWAIKEYSLMEIDTSFFQNMDGKELCKMNKEDFLRATTLYNTEVLLSHLSYLRESSLLAYNTTSHTDQSSRLSVKEDPSYDSVRRGAWGNNMNSGLNKSPPLGGAQTISKNTEQRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPTESSMYKYPSDISYMPSYHAHQQKVNFVPPHPSSMPVTSSSFFGAASQYWTSPTGGIYPNPNVPRHPNTHVPSHLGSYY
  
Inhibitor
Name:
BDBM50497662
Synonyms:
CHEMBL3360408
Type:
Small organic molecule
Emp. Form.:
C17H14Cl2N2O3
Mol. Mass.:
365.211
SMILES:
CNc1ccc(cc1)C(=O)CC1(O)C(=O)Nc2c1c(Cl)ccc2Cl
Structure:
Search PDB for entries with ligand similarity: