Reaction Details Report a problem with these data
Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50045915
Substrate
n/a
Meas. Tech.
ChEBML_28349
IC50
11±n/a nM
Citation
 Augelli-Szafran, CE; Blankley, CJ; Roth, BD; Trivedi, BK; Bousley, RF; Essenburg, AD; Hamelehle, KL; Krause, BR; Stanfield, RL Inhibitors of acyl-CoA:cholesterol acyltransferase. 5. Identification and structure-activity relationships of novel beta-ketoamides as hypocholesterolemic agents. J Med Chem 36:2943-9 (1993) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50045915
Synonyms:
CHEMBL316724 | N-(2,6-Diisopropyl-phenyl)-3-oxo-3-(1-phenyl-cyclopentyl)-propionamide
Type:
Small organic molecule
Emp. Form.:
C26H33NO2
Mol. Mass.:
391.5457
SMILES:
CC(C)c1cccc(C(C)C)c1NC(=O)CC(=O)C1(CCCC1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: