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Target
Neuronal acetylcholine receptor subunit beta-2
Ligand
BDBM50497820
Substrate
n/a
Meas. Tech.
ChEMBL_1451267 (CHEMBL3362770)
IC50
>300000±n/a nM
Citation
 Jepsen, TH; Jensen, AA; Lund, MH; Glibstrup, E; Kristensen, JL Synthesis and Pharmacological Evaluation of DH?E Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists. ACS Med Chem Lett 5:766-70 (2014) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit beta-2
Synonyms:
ACHB2_MOUSE | Chrnb2
Type:
PROTEIN
Mol. Mass.:
57114.19
Organism:
Mus musculus
Description:
ChEMBL_108396
Residue:
501
Sequence:
MARCSNSMALLFSFGLLWLCSGVLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSDVASLDDFTPSGEWDIIALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPTLLFLQQPRHRCARQRLRLRRRQREREGAGTLFFREGPAADPCTCFVNPASMQGLAGAFQAEPAAAGLGRSMGPCSCGLREAVDGVRFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTATTFLHSDHSAPSSK
  
Inhibitor
Name:
BDBM50497820
Synonyms:
CHEMBL3318899
Type:
Small organic molecule
Emp. Form.:
C16H21NO
Mol. Mass.:
243.344
SMILES:
[H][C@]12C[C@H](CC=C1CCN2C)OCc1ccccc1 |r,c:5|
Structure:
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