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Target
G protein-coupled receptor
Ligand
BDBM78940
Substrate
n/a
Meas. Tech.
ChEMBL_1456669 (CHEMBL3370504)
EC50
331±n/a nM
Citation
 Tschammer, N Allosteric modulation of the G protein-coupled US28 receptor of human cytomegalovirus: are the small-weight inverse agonist of US28 'camouflaged' agonists? Bioorg Med Chem Lett 24:3744-7 (2014) [PubMed]  Article 
Target
Name:
G protein-coupled receptor
Synonyms:
G protein-coupled receptor | US28
Type:
PROTEIN
Mol. Mass.:
40950.37
Organism:
Human cytomegalovirus
Description:
ChEMBL_109734
Residue:
354
Sequence:
MTPTTTTAELTTEFDYDEDAAPCVLTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKNNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFEKSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEACRVSQIIP
  
Inhibitor
Name:
BDBM78940
Synonyms:
METHIOTHEPIN | MLS000859918 | Methiothepin mesylate salt | SMR000326779 | cid_3039995 | mesylic acid;1-methyl-4-[3-(methylthio)-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine | methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazine | methanesulfonic acid;1-methyl-4-[3-(methylthio)-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine
Type:
Small organic molecule
Emp. Form.:
C20H24N2S2
Mol. Mass.:
356.548
SMILES:
CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1
Structure:
Search PDB for entries with ligand similarity: