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TargetLeukotriene A4 hydrolase
LigandBDBM50046331
Substrate/Competitorn/a
Meas. Tech.ChEMBL_96944
Ki 15000±n/a nM
Citation Yuan, WMunoz, BWong, CHHaeggström, JZWetterholm, ASamuelsson, B Development of selective tight-binding inhibitors of leukotriene A4 hydrolase. J Med Chem36:211-20 (1993) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Leukotriene A4 hydrolase
Name:Leukotriene A4 hydrolase
Synonyms:LTA-4 hydrolase | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H)
Type:Hydrolase; metalloprotease
Mol. Mass.:69280.41
Organism:Homo sapiens (Human)
Description:Human recombinant LTA4H.
Residue:611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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  Blast E-value cutoff:
BDBM50046331
NameBDBM50046331
Synonyms:((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-acetic acid | (3-Amino-2-hydroxy-4-phenyl-butyrylamino)-acetic acid | CHEMBL306868
TypeSmall organic molecule
Emp. Form.C12H16N2O4
Mol. Mass.252.2664
SMILESN[C@@H](Cc1ccccc1)[C@H](O)C(=O)NCC(O)=O
Structure
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n/a