Reaction Details Report a problem with these data
Target
Anionic trypsin
Ligand
BDBM50046345
Substrate
n/a
Meas. Tech.
ChEBML_212173
EC50
220±n/a nM
Citation
 Balasubramanian, N; St Laurent, DR; Federici, ME; Meanwell, NA; Wright, JJ; Schumacher, WA; Seiler, SM Active site-directed synthetic thrombin inhibitors: synthesis, in vitro and in vivo activity profile of BMY 44621 and analogs. An examination of the role of the amino group in the D-Phe-Pro-Arg-H series. J Med Chem 36:300-3 (1993) [PubMed]  Article 
Target
Name:
Anionic trypsin
Synonyms:
Anionic trypsin | TRY2_BOVIN | Trypsin II
Type:
PROTEIN
Mol. Mass.:
26281.39
Organism:
Bos taurus
Description:
ChEMBL_212177
Residue:
247
Sequence:
MHPLLILAFVGAAVAFPSDDDDKIVGGYTCAENSVPYQVSLNAGYHFCGGSLINDQWVVSAAHCYQYHIQVRLGEYNIDVLEGGEQFIDASKIIRHPKYSSWTLDNDILLIKLSTPAVINARVSTLLLPSACASAGTECLISGWGNTLSSGVNYPDLLQCLVAPLLSHADCEASYPGQITNNMICAGFLEGGKDSCQGDSGGPVACNGQLQGIVSWGYGCAQKGKPGVYTKVCNYVDWIQETIAANS
  
Inhibitor
Name:
BDBM50046345
Synonyms:
2-{[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidine-1-carbonyl]-amino}-3-phenyl-propionic acid | CHEMBL319396
Type:
Small organic molecule
Emp. Form.:
C21H30N6O5
Mol. Mass.:
446.5001
SMILES:
NC(=N)NCCCC(NC(=O)C1CCCN1C(=O)N[C@H](Cc1ccccc1)C(O)=O)C=O
Structure:
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