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Target
Thromboxane A2 receptor
Ligand
BDBM50008779
Substrate
n/a
Meas. Tech.
ChEMBL_207650 (CHEMBL811632)
Ki
15.3±n/a nM
Citation
 Nicolaï, E; Goyard, J; Benchetrit, T; Teulon, JM; Caussade, F; Virone, A; Delchambre, C; Cloarec, A Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists. J Med Chem 36:1175-87 (1993) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50008779
Synonyms:
(+) [9-(4-Chloro-benzyl)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]-acetic acid | (-) [9-(4-Chloro-benzyl)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]-acetic acid | CHEMBL280107 | [9-(4-Chloro-benzyl)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C21H19ClFNO2
Mol. Mass.:
371.832
SMILES:
OC(=O)CC1CCCc2c1n(Cc1ccc(Cl)cc1)c1ccc(F)cc21
Structure:
Search PDB for entries with ligand similarity: