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Target
Aromatase
Ligand
BDBM50047260
Substrate
n/a
Meas. Tech.
ChEBML_50687
IC50
3.5±n/a nM
Citation
 Furet, P; Batzl, C; Bhatnagar, A; Francotte, E; Rihs, G; Lang, M Aromatase inhibitors: synthesis, biological activity, and binding mode of azole-type compounds. J Med Chem 36:1393-400 (1993) [PubMed]  Article 
Target
Name:
Aromatase
Synonyms:
ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM
Type:
Enzyme
Mol. Mass.:
57888.92
Organism:
Homo sapiens (Human)
Description:
P11511
Residue:
503
Sequence:
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
  
Inhibitor
Name:
BDBM50047260
Synonyms:
4,4'-((1H-imidazol-1-yl)methylene)dibenzonitrile | 4-[(4-cyanophenyl)(1H-imidazol-1-yl)methyl]benzonitrile | 4-[4-cyanophenyl(1H-1-imidazolyl)methyl]benzonitrile | CGS-18320B | CHEMBL29482
Type:
Small organic molecule
Emp. Form.:
C18H12N4
Mol. Mass.:
284.3147
SMILES:
N#Cc1ccc(cc1)C(c1ccc(cc1)C#N)n1ccnc1
Structure:
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