Reaction Details Report a problem with these data
Target
Thromboxane A2 receptor
Ligand
BDBM50047303
Substrate
n/a
Meas. Tech.
ChEBML_212937
Kd
1.2±n/a nM
Citation
 Misra, RN; Brown, BR; Sher, PM; Patel, MM; Hall, SE; Han, WC; Barrish, JC; Kocy, O; Harris, DN; Goldenberg, HJ Interphenylene 7-oxabicyclo[2.2.1]heptane oxazoles. Highly potent, selective, and long-acting thromboxane A2 receptor antagonists. J Med Chem 36:1401-17 (1993) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50047303
Synonyms:
(3-{3-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-acetic acid | CHEMBL285596
Type:
Small organic molecule
Emp. Form.:
C29H38N2O5
Mol. Mass.:
494.6224
SMILES:
OC(=O)Cc1cccc(CC2C3CCC(O3)C2c2nc(co2)C(=O)NCCCCC2CCCCC2)c1 |TLB:9:10:15:13.12,THB:17:16:15:13.12|
Structure:
Search PDB for entries with ligand similarity: