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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM50184719
Substrate
n/a
Meas. Tech.
ChEMBL_1538243 (CHEMBL3737182)
Ki
4500±n/a nM
Citation
 Wang, Z; Sun, D; Johnstone, S; Cao, Z; Gao, X; Jaen, JC; Liu, J; Lively, S; Miao, S; Sudom, A; Tomooka, C; Walker, NP; Wright, M; Yan, X; Ye, Q; Powers, JP Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4. Bioorg Med Chem Lett 25:5546-50 (2015) [PubMed]  Article 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM50184719
Synonyms:
CHEMBL208116 | N-(5-fluoro-1H-benzo[d]imidazol-2-yl)-3-nitrobenzamide
Type:
Small organic molecule
Emp. Form.:
C14H9FN4O3
Mol. Mass.:
300.2447
SMILES:
[O-][N+](=O)c1cccc(c1)C(=O)Nc1nc2ccc(F)cc2[nH]1
Structure:
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