Reaction Details Report a problem with these data
Target
Retinoic acid receptor alpha
Ligand
BDBM50048288
Substrate
n/a
Meas. Tech.
ChEMBL_197413 (CHEMBL799802)
Ki
>10000±n/a nM
Citation
 Charpentier, B; Bernardon, JM; Eustache, J; Millois, C; Martin, B; Michel, S; Shroot, B Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. J Med Chem 38:4993-5006 (1996) [PubMed]  Article 
Target
Name:
Retinoic acid receptor alpha
Synonyms:
NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | RARA_HUMAN | Retinoic acid receptor alpha | Retinoic acid receptor alpha/Retinoid X receptor alpha | Retinoid X receptor gamma/retinoic acid receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50778.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1466191
Residue:
462
Sequence:
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
  
Inhibitor
Name:
BDBM50048288
Synonyms:
6-(3-Adamantan-1-yl-4-carboxy-phenyl)-naphthalene-2-carboxylic acid | CHEMBL145911
Type:
Small organic molecule
Emp. Form.:
C28H26O4
Mol. Mass.:
426.5036
SMILES:
OC(=O)c1ccc2cc(ccc2c1)-c1ccc(C(O)=O)c(c1)C12CC3CC(CC(C3)C1)C2 |TLB:29:24:31:30.28.27,29:28:31:23.24.25,THB:27:26:23:30.28.29,27:28:23:31.26.25|
Structure:
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