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TargetDopamine D2 receptor/Serotonin 2 (5-HT2) receptor
LigandBDBM50048801
Substrate/Competitorn/a
Meas. Tech.ChEMBL_62860
Ki 6.3±n/a nM
Citation Howard, HRLowe, JASeeger, TFSeymour, PAZorn, SHMaloney, PREwing, FENewman, MESchmidt, AWFurman, JSRobinson, GLJackson, EJohnson, CMorrone, J 3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents. J Med Chem39:143-8 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
Name:Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
Synonyms:DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DOPAMINE D2/D4 | DRD2 | Dopamine D2 receptor | Dopamine2-like
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:50931.60
Organism:Rattus norvegicus (rat)
Description:Receptor binding assays were performed using rat striatal membranes.
Residue:444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
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  Blast E-value cutoff:
BDBM50048801
NameBDBM50048801
Synonyms:6-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-3H-benzooxazol-2-one | CHEMBL35085
TypeSmall organic molecule
Emp. Form.C20H20N4O2S
Mol. Mass.380.463
SMILESO=c1[nH]c2ccc(CCN3CCN(CC3)c3nsc4ccccc34)cc2o1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a