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TargetPeroxisome proliferator-activated receptor gamma
LigandBDBM50049244
Substrate/Competitorn/a
Meas. Tech.ChEMBL_154537
EC50 13±n/a nM
Citation Willson, TMCobb, JECowan, DJWiethe, RWCorrea, IDPrakash, SRBeck, KDMoore, LBKliewer, SALehmann, JM The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem39:665-8 (1996) [PubMed]  Article
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Peroxisome proliferator-activated receptor gamma
Name:Peroxisome proliferator-activated receptor gamma
Synonyms:Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma
Type:PROTEIN
Mol. Mass.:57593.55
Organism:Mus musculus
Description:ChEMBL_1453700
Residue:505
Sequence:
MGETLGDSPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKNLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQL
LHVIKKTETDMSLHPLLQEIYKDLY
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  Blast E-value cutoff:
BDBM50049244
NameBDBM50049244
Synonyms:5-{4-[2-(Benzooxazol-2-yl-methyl-amino)-ethoxy]-benzyl}-thiazolidine-2,4-dione | BRL-48482 | CHEMBL17805
TypeSmall organic molecule
Emp. Form.C20H19N3O4S
Mol. Mass.397.448
SMILESCN(CCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1nc2ccccc2o1
Structure
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n/a