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Target
D(2) dopamine receptor
Ligand
BDBM50052526
Substrate
n/a
Meas. Tech.
ChEMBL_62559 (CHEMBL671490)
Ki
127±n/a nM
Citation
 Glase, SA; Akunne, HC; Heffner, TG; Jaen, JC; MacKenzie, RG; Meltzer, LT; Pugsley, TA; Smith, SJ; Wise, LD Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships. J Med Chem 39:3179-87 (1996) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50052526
Synonyms:
1-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-but-3-ynyl]-4-phenyl-1,2,3,6-tetrahydro-pyridine | CHEMBL108375
Type:
Small organic molecule
Emp. Form.:
C23H23NO2
Mol. Mass.:
345.4342
SMILES:
C(CN1CCC(=CC1)c1ccccc1)C#Cc1ccc2OCCOc2c1 |c:5|
Structure:
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