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Target
Glutamate receptor ionotropic, kainate 2
Ligand
BDBM50053078
Substrate
n/a
Meas. Tech.
ChEMBL_90595 (CHEMBL701552)
Ki
210.3±n/a nM
Citation
 Cantrell, BE; Zimmerman, DM; Monn, JA; Kamboj, RK; Hoo, KH; Tizzano, JP; Pullar, IA; Farrell, LN; Bleakman, D Synthesis of a series of aryl kainic acid analogs and evaluation in cells stably expressing the kainate receptor humGluR6. J Med Chem 39:3617-24 (1996) [PubMed]  Article 
Target
Name:
Glutamate receptor ionotropic, kainate 2
Synonyms:
GRIK2_RAT | Glur6 | Glutamate receptor ionotropic kainate 2 | Grik2 | Ionotropic glutamate receptor kainate 2/5
Type:
PROTEIN
Mol. Mass.:
102478.61
Organism:
Rattus norvegicus
Description:
ChEMBL_936439
Residue:
908
Sequence:
MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA
  
Inhibitor
Name:
BDBM50053078
Synonyms:
(2S,3S,4S)-3-Carboxymethyl-4-{1-[3-(3,3-diphenyl-propoxy)-phenyl]-vinyl}-pyrrolidine-2-carboxylic acid | CHEMBL330771
Type:
Small organic molecule
Emp. Form.:
C30H31NO5
Mol. Mass.:
485.5708
SMILES:
OC(=O)C[C@H]1[C@H](CN[C@@H]1C(O)=O)C(=C)c1cccc(OCCC(c2ccccc2)c2ccccc2)c1
Structure:
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