Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM50053147
Substrate
n/a
Meas. Tech.
ChEMBL_156184 (CHEMBL760953)
IC50
6±n/a nM
Citation
 Hagishita, S; Yamada, M; Shirahase, K; Okada, T; Murakami, Y; Ito, Y; Matsuura, T; Wada, M; Kato, T; Ueno, M; Chikazawa, Y; Yamada, K; Ono, T; Teshirogi, I; Ohtani, M Potent inhibitors of secretory phospholipase A2: synthesis and inhibitory activities of indolizine and indene derivatives. J Med Chem 39:3636-58 (1996) [PubMed]  Article 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM50053147
Synonyms:
(1-Aminooxalyl-3-biphenyl-2-ylmethyl-2-cyclopropyl-indolizin-8-yloxy)-acetic acid | CHEMBL121645
Type:
Small organic molecule
Emp. Form.:
C28H24N2O5
Mol. Mass.:
468.5006
SMILES:
NC(=O)C(=O)c1c(C2CC2)c(Cc2ccccc2-c2ccccc2)n2cccc(OCC(O)=O)c12
Structure:
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