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Target
Reverse transcriptase/RNaseH
Ligand
BDBM1945
Substrate
n/a
Meas. Tech.
ChEMBL_195079 (CHEMBL797533)
IC50
2000±n/a nM
Citation
 Genin, MJ; Poel, TJ; Yagi, Y; Biles, C; Althaus, I; Keiser, BJ; Kopta, LA; Friis, JM; Reusser, F; Adams, WJ; Olmsted, RA; Voorman, RL; Thomas, RC; Romero, DL Synthesis and bioactivity of novel bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs. J Med Chem 39:5267-75 (1997) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM1945
Synonyms:
(Alkylamino)piperidine BHAP Analog 1 | 2-N-[1-(1H-indol-2-ylcarbonyl)piperidin-4-yl]-2-N-methyl-3-N-(propan-2-yl)pyridine-2,3-diamine | CHEMBL151565
Type:
Small organic molecule
Emp. Form.:
C23H29N5O
Mol. Mass.:
391.5093
SMILES:
CC(C)Nc1cccnc1N(C)C1CCN(CC1)C(=O)c1cc2ccccc2[nH]1
Structure:
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