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Target
D(2) dopamine receptor
Ligand
BDBM50055722
Substrate
n/a
Meas. Tech.
ChEMBL_62399 (CHEMBL872888)
Ki
161±n/a nM
Citation
 Wustrow, DJ; Smith, WJ; Corbin, AE; Davis, MD; Georgic, LM; Pugsley, TA; Whetzel, SZ; Heffner, TG; Wise, LD 3-[[(4-Aryl-1-piperazinyl)alkyl]cyclohexyl]-1H-indoles as dopamine D2 partial agonists and autoreceptor agonists. J Med Chem 40:250-9 (1997) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50055722
Synonyms:
3-{4-[2-(4-Pyrimidin-2-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-1H-indole | CHEMBL87924
Type:
Small organic molecule
Emp. Form.:
C24H31N5
Mol. Mass.:
389.5364
SMILES:
C(CN1CCN(CC1)c1ncccn1)[C@H]1CC[C@@H](CC1)c1c[nH]c2ccccc12 |wU:17.22,wD:14.15,(13.38,-6.36,;14.7,-7.13,;16.04,-6.36,;16.02,-4.82,;17.34,-4.05,;18.68,-4.79,;18.7,-6.36,;17.37,-7.13,;20.02,-4.02,;20,-2.48,;21.34,-1.71,;22.66,-2.48,;22.68,-4.02,;21.35,-4.79,;12.04,-7.1,;10.72,-6.33,;9.38,-7.1,;9.38,-8.64,;10.72,-9.41,;12.03,-8.64,;8.1,-9.48,;8.03,-11.05,;6.54,-11.43,;5.69,-10.15,;4.15,-9.92,;3.6,-8.48,;4.59,-7.29,;6.1,-7.52,;6.65,-8.96,)|
Structure:
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