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Target
D(2) dopamine receptor
Ligand
BDBM50055733
Substrate
n/a
Meas. Tech.
ChEMBL_62399 (CHEMBL872888)
Ki
139±n/a nM
Citation
 Wustrow, DJ; Smith, WJ; Corbin, AE; Davis, MD; Georgic, LM; Pugsley, TA; Whetzel, SZ; Heffner, TG; Wise, LD 3-[[(4-Aryl-1-piperazinyl)alkyl]cyclohexyl]-1H-indoles as dopamine D2 partial agonists and autoreceptor agonists. J Med Chem 40:250-9 (1997) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50055733
Synonyms:
3-{4-[2-(4-Pyridin-2-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-1H-indole | CHEMBL86801
Type:
Small organic molecule
Emp. Form.:
C25H32N4
Mol. Mass.:
388.5484
SMILES:
C(CN1CCN(CC1)c1ccccn1)[C@H]1CC[C@H](CC1)c1c[nH]c2ccccc12 |wU:17.22,14.15,(13.4,-6.36,;14.73,-7.13,;16.07,-6.36,;17.4,-7.13,;18.74,-6.36,;18.72,-4.8,;17.37,-4.05,;16.05,-4.82,;20.05,-4.03,;21.38,-4.8,;22.72,-4.02,;22.7,-2.47,;21.37,-1.71,;20.03,-2.49,;12.06,-7.11,;12.05,-8.65,;10.73,-9.42,;9.4,-8.65,;9.4,-7.1,;10.73,-6.34,;8.11,-9.49,;8.05,-11.06,;6.56,-11.45,;5.7,-10.17,;4.16,-9.93,;3.61,-8.48,;4.6,-7.3,;6.11,-7.52,;6.66,-8.97,)|
Structure:
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