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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50058004
Substrate
n/a
Meas. Tech.
ChEMBL_202076 (CHEMBL811508)
Ki
2.9±n/a nM
Citation
 Waterhouse, RN; Mardon, K; Giles, KM; Collier, TL; O'Brien, JC Halogenated 4-(phenoxymethyl)piperidines as potential radiolabeled probes for sigma-1 receptors: in vivo evaluation of [123I]-1-(iodopropen-2-yl)-4-[(4-cyanophenoxy)methyl]pip eri dine. J Med Chem 40:1657-67 (1997) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50058004
Synonyms:
3-[4-(4-Iodo-phenoxymethyl)-piperidin-1-ylmethyl]-benzonitrile | CHEMBL417899
Type:
Small organic molecule
Emp. Form.:
C20H21IN2O
Mol. Mass.:
432.298
SMILES:
Ic1ccc(OCC2CCN(Cc3cccc(c3)C#N)CC2)cc1
Structure:
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