Reaction Details Report a problem with these data
Target
Cytosolic phospholipase A2
Ligand
BDBM50059543
Substrate
n/a
Meas. Tech.
ChEMBL_156041 (CHEMBL764349)
IC50
1600±n/a nM
Citation
 Lehr, M Synthesis, biological evaluation, and structure-activity relationships of 3-acylindole-2-carboxylic acids as inhibitors of the cytosolic phospholipase A2. J Med Chem 40:2694-705 (1997) [PubMed]  Article 
Target
Name:
Cytosolic phospholipase A2
Synonyms:
1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | CPLA2 | LDL-PLA(2) | Lysophospholipase | PA24A_BOVIN | PAF 2-acylhydrolase | PAF acetylhydrolase | PLA2G4 | PLA2G4A | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IVA | Platelet-activating factor acetylhydrolase
Type:
PROTEIN
Mol. Mass.:
85334.67
Organism:
Bos taurus
Description:
ChEMBL_156041
Residue:
749
Sequence:
MSFIDPYQHIIVEHHYSHKFTVVVLRATKVTKGTFGDMLDTPDPYVELFISSTPDSRKRTRHFNNDINPVWNETFEFILDPNQENILEITLMDANYVMDETLGTTTFPISSMKVGEKKQVPFIFNQVTEMILEMSLEVCSSPDLRFSMALCDQEKAFRQQRKENIKENMKKLLGPKNSEGLHSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYIAGLSGSTWYMSTLYSHPDFPEKGPEEINKELMKNVSHNPLLLLTPQKIKRYVESLWRKKSSGQPVTFTDIFGMLIGETLIHNRMNTTLSSLKEKVNTGQCPLPLFTCLHVKPDVSELMFADWVEFSPFEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSKGSTMEEELENITAKHIVSNDSSDSDDESQGPKGTEHEEAEREYQNDNQASWVQRMLMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPMSPLRDFTMQESLDEDELDAAVADPDEFEQIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDVEKDCPTIIHFVLANINFRKYKAPGVPRETNEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMYFNTLNNIDVIKNAIVESIEYRRQNPSRCSVSLSSVEARRFFNKEFLSKPTA
  
Inhibitor
Name:
BDBM50059543
Synonyms:
1-[2-(4-Carboxymethyl-phenoxy)-ethyl]-3-dodecanoyl-1H-indole-2-carboxylic acid | CHEMBL312824
Type:
Small organic molecule
Emp. Form.:
C31H39NO6
Mol. Mass.:
521.6445
SMILES:
CCCCCCCCCCCC(=O)c1c(C(O)=O)n(CCOc2ccc(CC(O)=O)cc2)c2ccccc12
Structure:
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