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Target
Mu-type opioid receptor
Ligand
BDBM50059761
Substrate
n/a
Meas. Tech.
ChEMBL_149139 (CHEMBL759230)
Ki
3.2±n/a nM
Citation
 Grauert, M; Bechtel, WD; Ensinger, HA; Merz, H; Carter, AJ Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as antagonists of the NMDA receptor-channel complex. J Med Chem 40:2922-30 (1997) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50059761
Synonyms:
(2R,6S,11R)-6,11-Dimethyl-3-((S)-2-methylsulfanyl-propyl)-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol | CHEMBL98650
Type:
Small organic molecule
Emp. Form.:
C18H27NOS
Mol. Mass.:
305.478
SMILES:
CS[C@@H](C)CN1CC[C@@]2(C)[C@@H](C)[C@H]1Cc1ccc(O)cc21 |THB:4:5:10:20.14.13|
Structure:
Search PDB for entries with ligand similarity: