Reaction Details Report a problem with these data
Target
Cytosolic phospholipase A2
Ligand
BDBM50060301
Substrate
n/a
Meas. Tech.
ChEMBL_52407 (CHEMBL665910)
IC50
7000±n/a nM
Citation
 Lehr, M Structure-activity relationships of (4-acylpyrrol-2-yl)alkanoic acids as inhibitors of the cytosolic phospholipase A2: variation of the substituents in positions 1, 3, and 5. J Med Chem 40:3381-92 (1997) [PubMed]  Article 
Target
Name:
Cytosolic phospholipase A2
Synonyms:
1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | CPLA2 | LDL-PLA(2) | Lysophospholipase | PA24A_BOVIN | PAF 2-acylhydrolase | PAF acetylhydrolase | PLA2G4 | PLA2G4A | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IVA | Platelet-activating factor acetylhydrolase
Type:
PROTEIN
Mol. Mass.:
85334.67
Organism:
Bos taurus
Description:
ChEMBL_156041
Residue:
749
Sequence:
MSFIDPYQHIIVEHHYSHKFTVVVLRATKVTKGTFGDMLDTPDPYVELFISSTPDSRKRTRHFNNDINPVWNETFEFILDPNQENILEITLMDANYVMDETLGTTTFPISSMKVGEKKQVPFIFNQVTEMILEMSLEVCSSPDLRFSMALCDQEKAFRQQRKENIKENMKKLLGPKNSEGLHSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYIAGLSGSTWYMSTLYSHPDFPEKGPEEINKELMKNVSHNPLLLLTPQKIKRYVESLWRKKSSGQPVTFTDIFGMLIGETLIHNRMNTTLSSLKEKVNTGQCPLPLFTCLHVKPDVSELMFADWVEFSPFEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSKGSTMEEELENITAKHIVSNDSSDSDDESQGPKGTEHEEAEREYQNDNQASWVQRMLMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPMSPLRDFTMQESLDEDELDAAVADPDEFEQIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDVEKDCPTIIHFVLANINFRKYKAPGVPRETNEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMYFNTLNNIDVIKNAIVESIEYRRQNPSRCSVSLSSVEARRFFNKEFLSKPTA
  
Inhibitor
Name:
BDBM50060301
Synonyms:
(1-Benzyl-3,5-dimethyl-4-octadecanoyl-1H-pyrrol-2-yl)-acetic acid | CHEMBL112566
Type:
Small organic molecule
Emp. Form.:
C33H51NO3
Mol. Mass.:
509.7629
SMILES:
CCCCCCCCCCCCCCCCCC(=O)c1c(C)c(CC(O)=O)n(Cc2ccccc2)c1C
Structure:
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